Major House Dust Mite Allergens Der p 1 And Der f 1 Degrade And Inactivate Lung Surfactant Proteins –A and –D*
نویسندگان
چکیده
‡ MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. OX1 3QU ‡‡ Institute of Infection, Immunity & Inflammation, University of Nottingham, Queen's Medical Centre, Nottingham, UK. NG7 2RD ¶ To whom correspondence may be addressed: MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. OX1 3QU. Tel. (+44)1865 275 348; Fax. (+44)1865 275 729; Email: [email protected]
منابع مشابه
Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy
BACKGROUND Vaccination with naked DNA encoding antigen induces cellular and humoral immunity characterized by the activation of specific Th1 cells. OBJECTIVE To evaluate the effects of vaccination with mixed naked DNA plasmids encoding Der p 1, Der p 2, Der p 3, Der f 1, Der f 2, and Der f 3, the major house dust mite allergens on the allergic inflammation to the whole house dust mites (HDM) ...
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Lung surfactant proteins (SP) A and D are calcium-dependent carbohydrate-binding proteins. In addition to playing multiple roles in innate immune defense such as bacterial aggregation and modulation of leukocyte function, SP-A and SP-D have also been implicated in the allergic response. They interact with a wide range of inhaled allergens, competing with their binding to cell-sequestered IgE re...
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BACKGROUND The aim of the present study was to determine the distribution of mite allergens in pig-farming environments in comparison to urban homes and the relationship between exposure to mite allergens and sensitization to the respective allergens in 100 pig farmers with work-related respiratory symptoms. METHODS The concentration of storage mite (Lep d 2) and house-dust-mite (Der p 1, Der...
متن کاملHouse dust mite allergens in domestic homes in Cheonan, Korea.
House dust mites produce inhalant allergens of importance to allergic patients. We measured the major group 1 allergens, Der p 1 and Der f 1, from the house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farina, respectively in 100 randomly selected domestic homes from Cheonan, Korea. Dust samples were collected by vacuuming from the living room floor and 1 mattress in each home...
متن کاملStandardization of House Dust Mite Extracts in Korea
PURPOSE House dust mites are the most important cause of respiratory allergy in Korea. Standardization of allergen extracts is essential for improving diagnostics and immunotherapeutics. This study was undertaken to evaluate the allergenicity of standardized house dust mite allergen extracts from Korean house dust mite isolates. METHODS Allergen extracts were prepared from cultured Korean hou...
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